PRF Gainesville FL
Platelet-rich fibrin prepared from your own blood, used in physician-led skin and regenerative protocols.
Complimentary consultation with Dr. Indianos, MD.
PRF (platelet-rich fibrin) is a concentrate prepared from a small sample of your own blood, spun in a centrifuge and used in select skin and regenerative protocols. If you are looking for PRF in Gainesville, FL, here is how it works at Bespoke Aesthetics: the process is physician-led from draw to injection. Dr. Carolyn Indianos, MD personally performs every PRF injection, and the blood draw and spin are done in-office under her direct supervision. PRF is offered as a standalone injectable (the under-eye area is a common request) or as an addition to microneedling. This page explains what PRF is, how it differs from PRP, and what a visit involves.
What PRF is
PRF is often described as a second-generation platelet concentrate. Like PRP, it starts with a standard blood draw. The difference is in the preparation. PRF is spun at a lower speed, for a shorter time, and without any anticoagulant. Because nothing interrupts the clotting process, the sample forms a soft fibrin matrix: a scaffold that holds platelets and a portion of your white blood cells.
That fibrin scaffold matters. Instead of releasing growth factors in a single early burst, the matrix is understood to release them gradually over several days as it breaks down. PRF is autologous, meaning it is prepared from your own blood, with no anticoagulant and no added preservatives.
PRF vs PRP: what actually differs
Patients often ask whether PRF is just a rebranded version of PRP. It is not. Both are platelet concentrates made from your own blood, but the preparation method changes how the final product looks and behaves.
| PRF (platelet-rich fibrin) | PRP (platelet-rich plasma) | |
|---|---|---|
| Spin speed | Lower speed, shorter spin | Higher speed, often two spin cycles |
| Anticoagulant | None | Added to keep the sample liquid |
| Growth-factor release | Gradual, over several days as the fibrin matrix breaks down | Faster, with an early peak |
| Texture | Soft gel that begins to set after preparation | Liquid, remains injectable |
Neither preparation is better across the board; they are simply suited to different protocols. Dr. Indianos offers both. You can read about the plasma version on our PRP page, and about microneedling with PRP as a combined treatment. Which preparation fits your situation is a clinical decision, and candidacy is determined at your consultation.
How Dr. Indianos uses PRF at Bespoke
Bespoke Aesthetics offers PRF in Gainesville, FL in two formats.
Standalone PRF injections. PRF can be injected on its own, without microneedling. The under-eye area is the most frequent request; the soft, slowly setting texture is one reason physicians select PRF for delicate, thin-skinned areas. It is also used in protocols designed to support overall skin quality.
PRF with microneedling. PRF can be applied during a microneedling session, where the channels created by the device allow the preparation to reach the skin directly. If you are weighing this against microneedling with PRP, that comparison is exactly the kind of question your consultation is for.
Within our biostimulators category, PRF sits alongside PRP and other biostimulator options. Each is used in different protocols, and none of them is a one-size answer. Candidacy is determined at your consultation, and individual results vary.
What a PRF visit looks like
Every PRF patient starts with a consultation with Dr. Indianos. The consultation is complimentary, credited toward treatment booked the same day (learn more). It covers your health history, an assessment of the areas you want addressed, and a direct conversation about whether PRF is a reasonable fit or whether a different protocol suits you better.
Treatment begins with a blood draw, the same as routine lab work. Your sample is spun on-site while you wait, then prepared and either injected or applied with microneedling. Mild redness or swelling at the treated area is common for a short period afterward. As with any injection, less common risks exist, and Dr. Indianos reviews them with you before treatment. You will leave with specific aftercare instructions, and because PRF is drawn and prepared fresh at each visit, nothing is ordered ahead and nothing is stored between appointments.
Location and Hours
Bespoke Aesthetics is located at 5010 W Newberry Rd, Suite C, Gainesville, FL 32607. We see patients by appointment. Call (352) 450-1004 to schedule, or reach us through the contact page.
This page is for informational purposes only and does not constitute medical advice. All treatment decisions are made individually between you and Dr. Indianos after a physician evaluation. Results vary by patient. No specific outcome is guaranteed.
Frequently Asked Questions
Common questions about treatment, protocols, and Bespoke’s clinical approach.
Medically reviewed by Dr. Carolyn Indianos, MD, Founder and Medical Director, Bespoke Aesthetics.
BEGIN YOUR JOURNEY
Ready for a physician-led PRF plan?
If you have been researching PRF and want a physician-led process from draw to injection, start with a consultation. Dr. Carolyn Indianos, MD holds an active Florida medical license and practices regenerative and aesthetic medicine at Bespoke Aesthetics in Gainesville. She personally performs every PRF injection.
Dr. Carolyn Indianos, MD • Regenerative & Aesthetic Medicine • Gainesville, FL
Related treatments in Gainesville: PRP · Microneedling + PRP · Biostimulators · Exosomes