GHK-Cu, the copper peptide, signals skin renewal, hair density, and tissue repair — physician-supervised at Bespoke Aesthetics.
GHK-Cu (glycyl-L-histidyl-L-lysine copper) is a naturally occurring copper-binding tripeptide with profound regenerative effects on skin, tissue, and cellular healing. At Bespoke Aesthetics, Dr. Carolyn Indianos, MD prescribes GHK-Cu therapy as part of comprehensive regenerative medicine protocols for skin rejuvenation, wound healing, and anti-aging support.
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GHK-Cu is a tripeptide naturally produced by the body that declines significantly with age. By age 60, GHK-Cu levels drop to less than one-third of youthful levels — contributing to slower wound healing, reduced collagen synthesis, and visible signs of aging. Therapeutic GHK-Cu replaces what aging depletes.
Laboratory research has linked GHK-Cu to activity across a wide range of genes involved in tissue repair, regeneration, and antioxidant defense. That evidence comes largely from cell and animal studies, and how it translates into a therapeutic effect at the doses used clinically has not been established. Key mechanisms include: stimulation of collagen and elastin synthesis, activation of fibroblast growth, anti-inflammatory effects, antioxidant protection from free radicals, support for hair follicle health, and acceleration of wound healing.
Skin rejuvenation: Increased collagen production reduces fine lines, improves skin elasticity, and enhances overall skin quality. Tissue support: GHK-Cu’s wound-healing activity is documented in laboratory and animal research. Whether it measurably speeds recovery from cosmetic procedures such as microneedling or laser treatment in humans has not been established in controlled trials, and we are not going to claim it accelerates your healing until that evidence exists. Hair follicle support: Improves hair density and reduces shedding. Anti-inflammatory: Reduces systemic inflammation. Antioxidant: Protects cells from oxidative damage.
Dr. Indianos personalizes GHK-Cu based on your goals, baseline labs, and any concurrent treatments. Forms include subcutaneous injection, topical formulations (for skin), and combination protocols stacked with other peptides (BPC-157 for healing, Sermorelin for systemic regeneration). Compounded by U.S. state-licensed 503A pharmacies. Compounded preparations are not FDA approved.
Adults seeking skin rejuvenation, wound healing support, post-procedure recovery acceleration, hair quality improvement, or comprehensive anti-aging protocols. Contraindications: active malignancy, copper sensitivity, pregnancy/breastfeeding.
GHK-Cu is generally well-tolerated. Possible mild injection site reactions (redness, mild swelling). Rare: mild headache or dizziness. Lab monitoring checks for problems. It does not confirm that the treatment is safe for you in advance, which is why any new or worsening symptom should be reported right away.
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Some preparations offered here are compounded and are not FDA approved. Compounded medications are prepared by state-licensed 503A pharmacies and are not reviewed by the FDA for safety, effectiveness, or quality before marketing. These services are not a treatment for any medical condition. Individual results vary, and no outcome is guaranteed.
Common questions about treatment, protocols, and Bespoke’s clinical approach.
Medically reviewed by Dr. Carolyn Indianos, MD, Founder and Medical Director, Bespoke Aesthetics.
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Dr. Carolyn Indianos, MD • Fellowship-Trained in Regenerative & Aesthetic Medicine • Gainesville, FL